Brush border enzymes in coeliac disease: histochemical evaluation.

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Brush border enzymes in coeliac disease: histochemical evaluation.

Two hundred and ninety four duodenal and jejunal mucosal biopsy specimens from patients with coeliac disease, treated and untreated, and other conditions were examined histologically and by histochemical staining for five peptidase and three disaccharidase enzymes to determine profiles of activity. Suppression of activity paralleled the histology with the following enzymes: lactase, trehalase, ...

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The surface membrane of the small intestine comes into contact with luminal nutrients, organisms, drugs and foreign antigens. The natural frontier between the body and the intestinal content is represented by the glycoproteins of the brush border membrane, which act as receptors, carriers and hydrolytic enzymes. Developmental variability of these glycoproteins may therefore regulate intestinal ...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1990

ISSN: 0021-9746

DOI: 10.1136/jcp.43.4.307